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Scientists design protein that prods cancerfighting Tcells
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computational image, a ligand protein binds to precise spots

T Cell Receptor (TCR) modified T cells

Upper left: Activation of T cells ...

The vaccine prompted the body to make killer T-cells designed to attack cancer cells

gene-edited cancer cells

The immune system is a complex apparatus that both protects the body and, in some cases, helps cancer destroy it.

The Fight Against Cancer Is Increasingly Personal

CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers

CRISPR gene editing helped create a new method for engineering T-cells to fight cancer.

Scientists are following various approaches using antibodies, the proteins produced by the immune system to

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nanoparticles targeting tumor cells

Chimeric antigen receptors

Credit: CC0 Public Domain

MIT biologists have designed a new peptide that can disrupt a key protein that many types

In the search for better treatments and prevention strategies, scientists are learning more about how cancer grows and survives, even in the most hostile ...

Such a therapy, which would be manufactured in bulk, could be directed to any cancer with the appropriate antibody switch.

CAR T cells: Engineering a cancer-fighting immune super solider - Cancer Research UK - Science blog

Tumor cells

Artist interpretation of a cancer cell dividing

sugars on the outside of a cancer cell

“But in order for that to happen, these therapies have to be tamed. They have to behave like pharmaceuticals where doses can be controlled and sensitively ...

Cancer cells displaying an Achilles' heel - the HER2 biomarker (red dots). Journal of Pathology Informatics CC-NC-SA

Scientists engineer a virus to take out cancer cells and their accomplices

A flowchart showing the process of reprogramming T cells.

Cells with lab-made DNA produce a new kind of protein, a 'holy grail' for synthetic biology - The Washington Post

The Most Promising Cancer Treatments In a Century Have Arrived—But Not For Everyone. Micrograph of T lymphocyte ...

A transparent tumour tomography showing T-cells attacking a tumour following treatment.

This is a schematic of how a "chimeric autoantibody receptor," or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease ...

CAR T-cell therapies are a new approach to cancer treatment and are being tested

NHS preparing to offer 'game-changing' cancer treatment | Science | The Guardian

Furthermore, certain side products which result from tryptophane degradation are toxic for T lymphocytes.

CAR-T Companies | CAR-T Companies: The Meteoric Rise Of Cellular Immunotherapies

CAR T Therapies and CRISPR are Fighting Cancer and Revolutionizing Medicine

A cartoon depicting T cells in capes fighting yellow blobs.

Umut Ulge and his fellow co-founders at Neoleukin Therapeutics will try to commercialize a cancer-fighting protein that was designed from scratch at the ...

Researchers redesign a cancer-busting protein—without the side effects

The making of a CAR T-cell attack.

T cell

Researchers Use CRISPR Gene-Editing Tool to Help Turn Immune Cells against Tumors

The surface of the nanoparticle is coated in proteins that bind selectively to T cells (yellow). The core of the nanoparticle contains DNA (white) and ...

car-t cell

Modified virus used to kill cancer cells

The engineered receptor on CAR T cells binds to an antigen on cancer cells. After binding, components of the receptor inside the T cell provide signals that ...

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Scanning electron micrograph (SEM) of T lymphocytes (green) bound to antigens on a cancer cell. © STEVE GSCHMEISSNER/SCIENCE SOURCE

Doctor melding DNA knight's armor together

CAR T-cell therapy. A type of treatment in which a patient's T cells (a type of immune cell) are changed in the laboratory so they will bind to cancer cells ...

2 Gene Therapy

The research team created CRISPR guides that would cause green fluorescent protein to ...

cells

A T cell hunts down and eliminates cancer cells. (Gillian Griffiths/Jonny Settle)

Engineered T Cells to Fight Cancer: T cell immunotherapy involves engineering a patient's own cells

Tumors' mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment's ...

Researchers at MIT and the University of California at San Diego have delivered artificial genetic circuits

One program is using the domains to control CAR expression. Obsidian's other programs could help turbocharge CAR T cells to better target solid tumors.

Scientists devised a pinpointed immunotherapy regimen that eradicated tumors throughout the body in mice. | Sagiv-Barfi et al., Science Translational ...

Cytokines and chemokines produced by tumor cells are indicated to alter the tumor suppressive functions of innate immune cells (natural killer cell, ...

Oncolytic Virus Therapy: Using Tumor-Targeting Viruses to Treat Cancer

A delicate molecular balance allows the immune system to tell friend from foe – cancer exploits this. Genentech

As stories of CAR-Ts' success began emerging, Wandless wondered if these misfolded regions of proteins, called destabilizing domains, could be used to ...

A team of scientists from Barcelona (IDIBELL-Institut Català d'Oncologia) and Philadelphia (Perelman School of Medicine) combined three of the most ...

Cancer Vaccines: How scientists are turning cancer against itself

Figure 1: How our immune systems detect cancer. Cancer cells present neo-antigens

Scientists Are Designing Artisanal Proteins for Your BodyScientists Are Designing Artisanal Proteins for Your Body

Materials Science

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Immunotherapy: How the Immune System Fights Cancer

Blocking the protein on the tumor (shown) or the protein on the immune cell can wake up T cells to attack the tumor.

Therefore, in cancer patients T cells will not receive the co-stimulatory signal from CD28 required for eliciting an immune response to fight cancer.

Antibodies carrying a toxic substance target the drug to cancer cells leading to the internalization of the poison and the death of ...

Personalized tumor vaccines keep cancer in check

Cancer cells

In recent years, researchers have looked at how to stimulate T-cells to combat tumors.

CAR T-Cell Therapy Approved for Some Children and Young Adults with Leukemia

CLONAL EXPANSION: As tumor cells divide, they accrue mutations that result in modified or novel peptide sequences that are unique to the cancer.

Festival posters

The CAR T cells engineered by Kite Pharma include an antibody-derived target binding domain, a costimulatory domain, and an essential activating domain.

A Protein Killer Could Treat All Cancers, and Possibly All Illnesses

Based on this shared basic mechanism of action, therapeutic antibodies are designed to block either of these checkpoint inhibitors or their receptors (Fig.

A BiTE® antibody construct is a type of fusion protein that is designed to harness the power of the immune system to treat cancer.

computational image, a ligand protein binds to precise spots

Download high-res image ...

T Cell Receptor (TCR) modified T cells

CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers

gene-edited cancer cells

The vaccine prompted the body to make killer T-cells designed to attack cancer cells

Serving the chemical, life science, and laboratory worlds

Such a therapy, which would be manufactured in bulk, could be directed to any cancer with the appropriate antibody switch.

nanoparticles targeting tumor cells

As stories of CAR-Ts' success began emerging, Wandless wondered if these misfolded regions of proteins, called destabilizing domains, could be used to ...

Credit: CC0 Public Domain

The immune system is a complex apparatus that both protects the body and, in some cases, helps cancer destroy it.

MIT biologists have designed a new peptide that can disrupt a key protein that many types

CAR T cells: Engineering a cancer-fighting immune super solider - Cancer Research UK - Science blog

Scientists are following various approaches using antibodies, the proteins produced by the immune system to

CRISPR gene editing helped create a new method for engineering T-cells to fight cancer.

A flowchart showing the process of reprogramming T cells.

Furthermore, certain side products which result from tryptophane degradation are toxic for T lymphocytes.

Vaccinating to treat cancer

sugars on the outside of a cancer cell

Researchers at MIT and the University of California at San Diego have delivered artificial genetic circuits

One program is using the domains to control CAR expression. Obsidian's other programs could help turbocharge CAR T cells to better target solid tumors.

NHS preparing to offer 'game-changing' cancer treatment | Science | The Guardian

A transparent tumour tomography showing T-cells attacking a tumour following treatment.

The Most Promising Cancer Treatments In a Century Have Arrived—But Not For Everyone. Micrograph of T lymphocyte ...

car-t cell

Doctor melding DNA knight's armor together

Artist interpretation of a cancer cell dividing

CAR T-cell therapies are a new approach to cancer treatment and are being tested

Stephen P. Schoenberger and Ezra Cohen

The research team created CRISPR guides that would cause green fluorescent protein to ...

In EBV-infected cells ...

A cartoon depicting T cells in capes fighting yellow blobs.

Catherine Offord

The surface of the nanoparticle is coated in proteins that bind selectively to T cells (yellow). The core of the nanoparticle contains DNA (white) and ...

Artificial Viruses Provoke the Immune System to Fight Cancer

The making of a CAR T-cell attack.

Modified virus used to kill cancer cells

Scanning electron micrograph (SEM) of T lymphocytes (green) bound to antigens on a cancer cell. © STEVE GSCHMEISSNER/SCIENCE SOURCE

The engineered receptor on CAR T cells binds to an antigen on cancer cells. After binding, components of the receptor inside the T cell provide signals that ...

The Genetics of Cancer

A team of scientists from Barcelona (IDIBELL-Institut Català d'Oncologia) and Philadelphia (Perelman School of Medicine) combined three of the most ...

Immunotherapy: How the Immune System Fights Cancer

2 Gene Therapy

cells

Oncolytic Virus Therapy: Using Tumor-Targeting Viruses to Treat Cancer

CLONAL EXPANSION: As tumor cells divide, they accrue mutations that result in modified or novel peptide sequences that are unique to the cancer.

Importance

Engineered T Cells to Fight Cancer: T cell immunotherapy involves engineering a patient's own cells

Download figure ...

Blocking the protein on the tumor (shown) or the protein on the immune cell can wake up T cells to attack the tumor.

A T cell hunts down and eliminates cancer cells. (Gillian Griffiths/Jonny Settle)

Festival posters

Cells with lab-made DNA produce a new kind of protein, a 'holy grail' for synthetic biology

NOT ALL BAD: Macrophages, such as the one shown in this artificially colored scanning electron micrograph, may help or hinder cancer's spread.

The CAR T cells engineered by Kite Pharma include an antibody-derived target binding domain, a costimulatory domain, and an essential activating domain.

A BiTE® antibody construct is a type of fusion protein that is designed to harness the power of the immune system to treat cancer.

Cancer cells

A delicate molecular balance allows the immune system to tell friend from foe – cancer exploits this. Genentech

Checkpoint proteins, such as PD-L1 on tumor cells and PD-1 on T cells, help keep immune responses in check. The binding of PD-L1 to PD-1 keeps T cells from ...

New Target Antigens for CAR T Cells

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CAR-T cells: the long and winding road to solid tumors | Cell Death & Disease

Scientists Are Designing Artisanal Proteins for Your BodyScientists Are Designing Artisanal Proteins for Your Body

10 Breakthrough Technologies 2016: Immune Engineering - MIT Technology Review

Download figure ...

Immune Engineering

Illustration of T cell activation in uveitis.

Rewriting Life. U.S. doctors plan to treat cancer ...

CAR T-Cell Therapy: Changing the Way Cancer is Treated

Cancer cells displaying an Achilles' heel - the HER2 biomarker (red dots). Journal of Pathology Informatics CC-NC-SA

... Download full-size image

CAR T-cell therapy. A type of treatment in which a patient's T cells (a type of immune cell) are changed in the laboratory so they will bind to cancer cells ...

IMPROVING CAR T CELLS: In addition to a specific cancer-targeting antibody, a transmembrane component, and a signaling domain that amplifies the activation ...

10 Breakthrough Technologies 2016: Immune Engineering - MIT Technology Review

Starving Cancer

In 2015, Amgen and Kite Pharma launched a cancer immunotherapy collaboration to develop and commercialize chimetic antigen receptor (CAR) T cells, a novel, ...

Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

CAR-T therapy infographic

As more researchers entered the field and initiated small clinical tests, they began to produce enticing anecdotes. Russell recalls the case of an ...

GRAPHIC: V. ALTOUNIAN/SCIENCE

synthetic sialic acids on cancer cells

Rewriting Life. Biotech's Coming Cancer Cure

Figure: Upper left: Activation of T cells requires that the T-cell receptor binds to structures on other immune cells recognized as ”non-self”. A protein ...

Controlling CAR-T: How scientists plan to make the engineered T cell therapy safer, and work for more cancers